Does Training Your Weekly Volume in Fewer Sets With Longer Effort Build the Same Muscle?

Here's a question I get from lifters who are chronically short on time: instead of grinding through three or four straight sets, can you do one long set that keeps the muscle under continuous tension and call it a day? The trendy version of this is "myo-reps" or cluster-style work, where you take one set close to failure, rest ten to twenty seconds, and squeeze out more mini-clusters. The logic is that once you've recruited the high-threshold motor units, brief rest lets you keep hammering those same fibers without a full fresh set each time.